کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10966741 | 1102787 | 2013 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Development and preclinical evaluation of safety and immunogenicity of an oral ETEC vaccine containing inactivated E. coli bacteria overexpressing colonization factors CFA/I, CS3, CS5 and CS6 combined with a hybrid LT/CT B subunit antigen, administered al
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کلمات کلیدی
LTBCTBETECGMPETEC vaccinedmLTenzyme linked immunosorbent assay - آنزیم تست ایمونوسیورسانس مرتبط استMucosal immunity - ایمنی مخاطیELISA - تست الیزاGood Manufacturing Practice - تمرین تولید خوبHeat labile toxin - سم زدایی از حرارتColonization factors - عوامل استعمارColonization factor - فاکتور کلونیزاسیونVaccine - واکسنImmune responses - پاسخ های ایمنیcholera toxin B subunit - کلسترول توکسین B واحد
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Development and preclinical evaluation of safety and immunogenicity of an oral ETEC vaccine containing inactivated E. coli bacteria overexpressing colonization factors CFA/I, CS3, CS5 and CS6 combined with a hybrid LT/CT B subunit antigen, administered al Development and preclinical evaluation of safety and immunogenicity of an oral ETEC vaccine containing inactivated E. coli bacteria overexpressing colonization factors CFA/I, CS3, CS5 and CS6 combined with a hybrid LT/CT B subunit antigen, administered al](/preview/png/10966741.png)
چکیده انگلیسی
Two test vaccines were prepared under GMP: (1) A prototype E. coli CFA/I-only formalin-killed whole-cell + LCTBA vaccine, and (2) A “complete” inactivated multivalent ETEC-CF (CFA/I, CS3, CS5 and CS6 antigens) whole-cell + LCTBA vaccine. These vaccines, when given intragastrically alone or together with dmLT in mice, were well tolerated and induced strong intestinal-mucosal IgA antibody responses as well as serum IgG and IgA responses to each of the vaccine CF antigens as well as to LT B subunit (LTB). Both mucosal and serum responses were further enhanced (adjuvanted) when the vaccines were co-administered with dmLT. We conclude that the new multivalent oral ETEC vaccine, both alone and especially in combination with the dmLT adjuvant, shows great promise for further testing in humans.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 31, Issue 20, 7 May 2013, Pages 2457-2464
Journal: Vaccine - Volume 31, Issue 20, 7 May 2013, Pages 2457-2464
نویسندگان
J. Holmgren, L. Bourgeois, N. Carlin, J. Clements, B. Gustafsson, A. Lundgren, E. Nygren, J. Tobias, R. Walker, A.-M. Svennerholm,