Vaccination in children with inborn errors of metabolism

► The impact of the available vaccines on children with IEMs may vary. ► Severe metabolic crises after vaccination have been rarely reported. ► Vaccines should be cautiously administered in IEMs with significant catabolic event. ► Immune deficiency in a number of IEMs may lead to an inadequate immune response. ► Live attenuated viruses vaccines should not be given in IEMs with severe immunodeficiency.