کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10967410 | 1102830 | 2012 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
HLA-DR specific monoclonal antibodies block lymphoproliferative response to measles vaccine in vitro: A pilot study
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
PBMCCTLMoAbCell-mediated immunity (CMI)MVVMMRLPAMonoclonal antibody - آنتی بادی مونوکلونالImmune memory - حافظه ایمنیmeasles–mumps–rubella - سرخک - تخم مرغ - سرخجهperipheral blood mononuclear cells - سلول های تک هسته ای خون محیطیstimulation index - شاخص تحریکCytotoxic T lymphocytes - لنفوسیت های T سیتوتوکسیکImmunity - مصونیتplaque forming units - واحدهای تشکیل پلاکVaccine - واکسنMeasles virus - ویروس سرخکMonoclonal antibodies - پادتنهای تَکتیرهpfu - پفو
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Humoral and cell-mediated immune responses are important in protection against measles. Non-response to vaccination has been associated with specific HLA-DR and HLA-DQ alleles; however, little is known about the relative importance of these alleles in the cellular immune response induced by measles virus vaccine. To investigate the role of HLA-DR/DQ class II restriction, a small pilot study was conducted. Lymphoproliferation assays using class II DR and DQ-specific monoclonal antibodies (MoAb) were performed at one week and two weeks post immunization with MMRII vaccine. The mean stimulation index (SI) was 4.4 and 5.3 at one and two weeks with reductions in SI of 47.6% and 70.2%, respectively, following the addition of DR-specific MoAb (p < 0.001). These results clearly show that a significant proportion of the cell-mediated immune response to measles virus vaccine, as measured by SI, is HLA-DR restricted.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 30, Issue 47, 19 October 2012, Pages 6628-6631
Journal: Vaccine - Volume 30, Issue 47, 19 October 2012, Pages 6628-6631
نویسندگان
David M. Phelan, Gregory A. Poland,