کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10967447 | 1102831 | 2013 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Genetic variants within the MHC region are associated with immune responsiveness to childhood vaccinations
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کلمات کلیدی
Haemophilus influenza type bpNPScpsDiphtheria, tetanus, and pertussisPCV7DTaPHBsAgIPVHuman leukocyte antigen - آنتی ژن لوسکسی انسانHLA - آنتیژن گلبول سفید انسانیimmunoglobulin - ایمونوگلوبولینLinkage disequilibrium - عدم تعادل پیوستگیMHC - مجموعه سازگاری بافتی اصلیmajor histocompatibility complex - مجموعه سازگاری بافتی اصلیodds ratio - نسبت شانس هاHBV - هپاتیت بHib - هیبinactivated polio vaccine - واکسن فلج اطفال غیر فعال شدهhepatitis B virus - ویروس هپاتیت بیImmune response - پاسخ یا واکنش ایمنیPneumococcal polysaccharides - پلی ساکارید های پنوموکوکGenetic polymorphism - پلیمورفیسم ژنتیکیSingle nucleotide polymorphism - پلیمورفیسم تک نوکلئوتیدیSNP - چندریختی تک-نوکلئوتید
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The influence of genetic variability within the major histocompatibility complex (MHC) region on variations in immune responses to childhood vaccination was investigated. The study group consisted of 135 healthy infants who had been immunized with hepatitis B (HBV), 7-valent pneumococcal conjugate (PCV7), and diphtheria, tetanus, acellular pertussis (DTaP) vaccines according to standard childhood immunization schedules. Genotype analysis was performed on genomic DNA using Illumina Goldengate MHC panels (Mapping and Exon Centric). At the 1 year post vaccination check-up total, isotypic, and antigen-specific serum antibody levels were measured using multiplex immunoassays. A number of single nucleotide polymorphisms (SNPs) within MHC Class I and II genes were found to be associated with variations in the vaccine specific antibody responses and serum levels of immunoglobulins (IgG, IgM) and IgG isotypes (IgG1, IgG4) (all at p < 0.001). Linkage disequilibrium patterns and functional annotations showed that significant SNPs were strongly correlated with other functional regulatory SNPs. These SNPs were found to regulate the expression of a group of genes involved in antigen processing and presentation including HLA-A, HLA-C, HLA-G, HLA-H, HLA-DRA, HLA-DRB1, HLA-DRB5, HLA-DQA1, HLA-DQB1, HLA-DOB, and TAP-2. The results suggest that genetic variations within particular MHC genes can influence immune response to common childhood vaccinations, which in turn may influence vaccine efficacy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 31, Issue 46, 4 November 2013, Pages 5381-5391
Journal: Vaccine - Volume 31, Issue 46, 4 November 2013, Pages 5381-5391
نویسندگان
Berran Yucesoy, Yerkebulan Talzhanov, Victor J. Johnson, Nevin W. Wilson, Raymond E. Biagini, Wei Wang, Bonnie Frye, David N. Weissman, Dori R. Germolec, Michael I. Luster, Michael M. Barmada,