کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10967972 1102857 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prospects for oral replicating adenovirus-vectored vaccines
ترجمه فارسی عنوان
چشم انداز واکسن های واکسن آدنویروس تکرار کننده دهان
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی
Orally delivered replicating adenovirus (Ad) vaccines have been used for decades to prevent adenovirus serotype 4 and 7 respiratory illness in military recruits, demonstrating exemplary safety and high efficacy. That experience suggests that oral administration of live recombinant Ads (rAds) holds promise for immunization against other infectious diseases, including those that have been refractory to traditional vaccination methods. Live rAds can express intact antigens from free-standing transgenes during replication in infected cells. Alternatively, antigenic epitopes can be displayed on the rAd capsid itself, allowing presentation of the epitope to the immune system both prior to and during replication of the virus. Such capsid-display rAds offer a novel vaccine approach that could be used either independently of or in combination with transgene expression strategies to provide a new tool in the search for protection from infectious disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 31, Issue 32, 11 July 2013, Pages 3236-3243
نویسندگان
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