Consecutive CT in vivo lung imaging as quantitative parameter of influenza vaccine efficacy in the ferret model

► We evaluated efficacy of an influenza vaccine by means of CT-scan in the ferret. ► Longitudinal in vivo scanning allows quantification of changes in aerated lung volume. ► Immunisation protects from a significant initial severe increase in aerated lung volume seen in unprotected controls. ► Immunisation protects from major increase of relative lung weight.