Antigenic mimicry-mediated anti-prion effects induced by bacterial enzyme succinylarginine dihydrolase in mice

► In this study, we immunized mice with the bacterial molecules SADH(E) and SADH(S). ► These molecules carry a sequence similar to the 6H4 anti-prion epitope. ► The immunization elicited anti-prion Abs and attenuated prion disease in mice. ► Antigenic mimicry-based prion vaccines might be a new type of prion vaccine.