کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10968866 | 1102910 | 2011 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Immunological priming induced by a two-dose series of H5N1 influenza antigen, administered alone or in combination with two different formulations of AS03 adjuvant in adults: Results of a randomised single heterologous booster dose study at 15 months
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کلمات کلیدی
vaccine response ratePIMDFDACBERVRRAS03ANCOVASAETVCGMTGSKGlaxoSmithKlineMedDRAATP - آدنوزین تری فسفات یا ATPaccording to protocol - با توجه به پروتکلanalysis of covariance - تجزیه و تحلیل کوواریانسSPR - تشدید پلاسمون سطحیlower limit - حد پایینMedical Dictionary for Regulatory Activities - دیکشنری پزشکی برای فعالیت های نظارتیH5N1 subtype - زیر نوع H5N1World Health Organization - سازمان بهداشت جهانیFood and Drug Administration - سازمان غذا و داروadverse event - عارضه جانبی یا عوارض جانبیSerious adverse event - عوارض جانبی جدیconfidence interval - فاصله اطمینانCenter for Biologics Evaluation and Research - مرکز ارزیابی و تحقیق زیست شناسیhaemagglutination inhibition - مهار hemagglutinationgeometric mean titres - میانگین تیترهای هندسیSeroconversion rate - میزان سرولوژیSeroprotection rate - میزان محافظت از سرطانInfluenza vaccines - واکسن آنفلوانزاInfluenza A virus - ویروس آنفولانزا A total vaccinated cohort - کل واکسن کوهورتWHO - کهSCR - یکسوساز کنترلشده با سیلیکون
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Immunological priming induced by a two-dose series of H5N1 influenza antigen, administered alone or in combination with two different formulations of AS03 adjuvant in adults: Results of a randomised single heterologous booster dose study at 15 months Immunological priming induced by a two-dose series of H5N1 influenza antigen, administered alone or in combination with two different formulations of AS03 adjuvant in adults: Results of a randomised single heterologous booster dose study at 15 months](/preview/png/10968866.png)
چکیده انگلیسی
One influenza pandemic preparedness strategy involves priming a population with a pre-pandemic subtype-specific vaccine and boosting the immunological response at the time of the pandemic with a strain-matched vaccine. In the current study, adults (n = 469) randomised 15 months previously to receive an A/Indonesia/5/2005 (H5N1) influenza vaccine (3.75 μg haemagglutinin antigen [HA]) administered alone or in combination with an oil-in-water emulsion based Adjuvant System containing 11.86 mg (AS03A) or 5.93 mg (AS03B) tocopherol per dose, received one booster dose of A/turkey/Turkey/1/2005 (H5N1) vaccine (3.75 μg HA) with or without AS03A. An anamnestic antibody response that met US regulatory acceptance criteria was observed 15 months after priming. Although superior immunogenicity of AS03-adjuvanted compared to unadjuvanted priming was not demonstrated, higher antibody titres which persisted longer were seen when both priming and boosting regimens were adjuvanted. This may affect duration of response or heterologous immunity. The booster vaccines had a clinically acceptable safety/reactogenicity profile after adjuvanted or unadjuvanted priming. This study has been registered at www.clinicaltrials.govNCT00771615.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 29, Issue 37, 26 August 2011, Pages 6408-6418
Journal: Vaccine - Volume 29, Issue 37, 26 August 2011, Pages 6408-6418
نویسندگان
George Risi, Louise Frenette, Joanne M. Langley, Ping Li, Dennis Riff, Eric Sheldon, David W. Vaughn, Louis Fries,