Dose sparing intradermal trivalent influenza (2010/2011) vaccination overcomes reduced immunogenicity of the 2009 H1N1 strain

► Reduced immunogenicity of the H1N1 component of the current TIV demonstrated. ► Reduced immunogenicity of the H1N1 component overcome by intradermal vaccination. ► Efficacy between two different intradermal devices compared. ► Superior efficacy of intradermal over conventional intramuscular vaccination demonstrated.