Diurnal stability and long-term repeatability of neurometabolites using single voxel 1H magnetic resonance spectroscopy

In vitro MRS showed no diurnal effects and minimal variation in metabolite levels. Most PCG metabolites are not altered diurnally. The low in vivo variability of metabolite concentration supports the use of localised MRS on clinical 3 T scanners for reliable neurometabolic profiling of the brain.