کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11025733 | 1666522 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
MicroRNAs as biological regulators in skin disorders
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کلمات کلیدی
ECMprecursor miRNARUNX3PDGFTGFpri-miRNAMIRFGFPrimary miRNA - miRNA اولیهskin disorders - اختلالات پوستیScleroderma - اسکلرودرمی Wound Healing - التیام زخمtransforming growth factor - تبدیل فاکتور رشدsingle-stranded - تک رشتهRISC - خطرdermatomyositis - درماتومیوزیتDouble stranded - دو رشتهmicroRNAs - ریز آرانایplatelet-derived growth factor - فاکتور رشد حاصل از پلاکتfibroblast growth factor - فاکتور رشد فیبروبلاستRunt-related transcription factor 3 - فاکتور رونویسی مرتبط با روت 3RNA Induced Silencing Complex - مجتمع خاموش کننده RNA منجر شده استMicroRNA - میکرو RNA polymerase chain reaction - واکنش زنجیره ای پلیمرازPCR - واکنش زنجیرهٔ پلیمرازPsoriasis - پسوریازیس
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
microRNAs are being investigated as promising therapeutic targets and biomarkers for different disease conditions. miRNAs serve as essential regulators of cell differentiation, proliferation and survival. The involvement of miRNAs in the functioning and regulation of the skin cells and skin diseases is a rapidly advancing area in dermatological research. miRNAs have been identified to play a key role in the pathogenesis, diagnosis, and treatment of the skin diseases. Skin is one of the largest organs of the body, primarily functioning as the first line of defence against external insults including bacteria, virus and other pathogens. Various miRNAs have been identified to demonstrate significant effects in various skin inflammatory conditions such as wounds, cancer, psoriasis, scleroderma, dermatomyositis. The current review explores the possible roles of the miRNAs in skin disorders and reports relating to the clinical trials involving skin diseases and miRNAs. The review has also compiled the information of the databases available, which correlates the miRNAs with different diseases and give details about targeting interactions of miRNA.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 108, December 2018, Pages 996-1004
Journal: Biomedicine & Pharmacotherapy - Volume 108, December 2018, Pages 996-1004
نویسندگان
Gautam Singhvi, Prachi Manchanda, Vamshi Krishna Rapalli, Sunil Kumar Dubey, Gaurav Gupta, Kamal Dua,