کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1247936 | 1495912 | 2013 | 13 صفحه PDF | دانلود رایگان |
• Mass spectrometry-based metabolomics applied to study diet-related diseases.
• Selected biomarkers aid understanding of disease mechanisms.
• Different analytical platforms (CE–MS, GC–MS, LC–MS) offer different information.
• Integrated biology (different omics) reveals more information on pathway regulation.
We discuss a range of mass spectrometry techniques applied to metabolomics of diet-related diseases, including the combination of metabolomics with other studies to reveal systems properties of the diseases. Since it is difficult to set up a clinical study based on the probability of finding exploratory biomarkers to be applied in wide-population screening, many metabolomics studies have revealed biomarkers of the complications of the disease, which could have power as prognostic biomarkers.
Journal: TrAC Trends in Analytical Chemistry - Volume 52, December 2013, Pages 61–73