Secondary phosphine oxides: Versatile ligands in transition metal-catalyzed cross-coupling reactions

This review describes the development in the use of secondary phosphine oxides ligands in transition-metal-catalyzed oxidative coupling reactions to the formation of CC, CN and CS bonds. Also the developments in the recent literature are highlighted in the areas of cycloaddition, coupling of acyl halide with organometallic reagents, oxidations and other reactions. The secondary phosphine oxides are known to exist in the tautomeric forms and are configurationally stable; this property enables a variety of useful transformations for accessing optically active organophosphorus compounds which are useful in the formation of CC bonds and asymmetric hydrogenation reactions. Finally, the mechanistic aspect employing DFT technique in these oxidative coupling reactions is described in this article.

Figure optionsDownload high-quality image (184 K)Download as PowerPoint slideHighlights
► Secondary phosphine oxides (SPOs) are air and moisture stable ligands.
► Combination of SPOs and transition metals as catalysts in CC, CN and CS bond forming reactions has been discussed.
► Catalytic activity was also described on cycloaddition and asymmetric reactions.
► Mechanistic aspect was discussed using DFT technique.