کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
13424348 | 1841839 | 2019 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
DNA-methylation of the dopamin receptor 2 gene is altered during alcohol withdrawal
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کلمات کلیدی
OCDSmRNADRD2EMMDATCpGDNA - DNA یا اسید دزوکسی ریبونوکلئیکdeoxyribonucleic acid - اسید deoxyribonucleicAlcohol - الکلDopamine transporter - انتقال دهنده دوپامینGene expression - بیان ژنstandard error - خطای استانداردDopamine - دوپامینDiagnostic and Statistical Manual of Mental Disorders, 4th edition - راهنمای تشخیصی و آماری اختلالات روانی، ویرایش چهارمmessenger ribonucleic acid - رسوب ریبونوکلئیک اسیدCytosine-phosphate-Guanine - سیتوزین-فسفات-گوانینobsessive compulsive drinking scale - مقیاس نوشیدن اجباری وسواسیNicotine - نیکوتین Alcohol dependence - وابستگی الکلیpolymerase chain reaction - واکنش زنجیره ای پلیمرازPCR - واکنش زنجیرهٔ پلیمرازdopamine receptor D2 - گیرنده Dopamine D2
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
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چکیده انگلیسی
The dopaminergic neurotransmission is known to be of crucial importance in addictive behavior. Epigenetic regulation like methylation of DNA influences the function of dopaminergic transmission. The present study investigated alterations of DNA methylation in the dopamine D2 receptor (DRD2)-gene in patients suffering from alcohol dependence. The study sample consists of 99 alcohol dependent males admitted for alcohol withdrawal treatment and a control group of 33 healthy participants. Blood samples underwent bisulfite sequencing to determine levels of DNA-methylation of the promoter region of the DRD2 gene. Mixed linear modeling was used to test differences between patients and controls, course of methylation during detoxification. While DRD2-gene methylation did not differ significantly between patients and controls, we found a significant increase of DRD2-gene methylation during alcohol withdrawal/early abstinence. Craving, measured with the Obsessive Compulsive Drinking Scale (OCDS), was significantly associated with DRD2-gene methylation. Furthermore, smoking significantly influenced DRD2-gene methylation in both, patients and controls. As in other types of addictive disorders, DRD2-gene methylation is altered during alcohol withdrawal/early abstinence. The findings regarding an association with alcohol craving and tobacco consumption point towards a crucial role of DRD2-gene methylation in the neurobiology of addictive behavior.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Neuropsychopharmacology - Volume 29, Issue 11, November 2019, Pages 1250-1257
Journal: European Neuropsychopharmacology - Volume 29, Issue 11, November 2019, Pages 1250-1257
نویسندگان
Thomas Hillemacher, Mathias Rhein, Alexandra Burkert, Annemarie Heberlein, Julia Wilhelm, Alexander Glahn, Marc Andre Nicolas Muschler, Kai G. Kahl, Johannes Kornhuber, Stefan Bleich, Helge Frieling,