Synthesis of novel spirostanic saponins and their cytotoxic activity

This study was carried out to assess the cytotoxicity of several new synthetic steroidal saponins against the human myeloid leukemia cell lines (HL-60 and U937) and against human melanoma cells (SK-MEL-1). Several diosgenyl glycosides analyzed showed strong cell growth inhibition which was associated with alterations in cell cycle progression and induction of apoptosis. Studies of cytochrome c release and caspase-9 activation suggest a main role of the intrinsic pathway of apoptosis in the mechanism of cytotoxicity caused by this kind of compounds.

To create your abstract, type over the instructions in the template box below. Fonts or abstract dimensions should not be changed or altered. This paper describes the cytotoxic effect induced by new synthetic spirostanic saponins on human tumor cell lines (human myeloid leukemia and human melanoma cells).Figure optionsDownload as PowerPoint slide