Studies of interactions between uracil-based hybrid molecules and P-glycoprotein—Search for multidrug resistance modulators

The hybrid molecules having structural features of anticancer drug, 5-fluorouracil, and MDR modulator, propafenone, have been studied for their interactions with P-glycoprotein (P-gp). Some of the molecules (5, 8, and 9) show considerable interactions with P-gp and could be the potential candidates for their in vivo evaluation as MDR modulators. Further investigations show the dependence of P-gp interacting properties of these compounds on their physico-chemical parameters like log P and total polar surface area.

The hybrid molecules (C), having the structural features of anticancer drug 5-fluorouracil (A) and MDR modulator, propafenone (B), have been studied for their interactions with P-glycoprotein.Figure optionsDownload as PowerPoint slide