Perspectives of endoscopic plasma applications

The development of the Plasma Gun, generating Pulsed Atmospheric-pressure Plasma Streams inside long and small diameter tubes flushed with low gas flow rates, is reported with a special emphasis on the first demonstration and perspectives for in vivo endoscopic applications. The safe delivery and antitumor action of plasma have been achieved for in vivo colorectal and pancreatic cancers. Plasma delivery and plasma triggered inflammation inside mouse lungs were performed through an endoscopic protocol. The study of plasma splitting or transfer across metallic sections or dielectric barriers is documented and open up opportunities for self guided and low invasive plasma endoscopy.