کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1717285 | 1013437 | 2006 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The potential (radio-)biological impact of launch vibration
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
سایر رشته های مهندسی
مهندسی هوافضا
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چکیده انگلیسی
The differences observed between microgravity exposed samples and 1Ãg control samples on ground in a typical cell biological space experiment may be explained by unwanted side-effects like cosmic rays, launch vibrations or acceleration effects. This study investigated the impact of vibrational stress accompanying a typical launch in the field of radiobiology. Cultures of primary bone marrow cells were hard-mounted on a vibration table in a direction parallel (launch direction) and perpendicular to the cell culture's substrate. The cell cultures were then vibrated according to the qualification tests of Biobox space hardware. The g-levels in those separate directions measured 11.3Ãg and 4.5Ãg rms, respectively. Expression levels of six genes controlling apoptosis or genome damage/repair (c-Fos, Gadd45a, p21, Mdm2, Bax and Hspa4) were quantified with real-time PCR based on a panel of stable genes. A significant change in gene expression was seen in the launch direction. Considering the one-shot philosophy of space experimentation, simultaneous vibration of ground samples at launch of experiments should be mandatory for biological experiments.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Astronautica - Volume 58, Issue 9, May 2006, Pages 456-463
Journal: Acta Astronautica - Volume 58, Issue 9, May 2006, Pages 456-463
نویسندگان
Philippe Baert, Tim Van Cleynenbreugel, Jo Vandesompele, Sofie De Schynkel, Jos Vander Sloten, Patrick Van Oostveldt,