کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
173075 458575 2011 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Simulation of freezing step in vial lyophilization using finite element method
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Simulation of freezing step in vial lyophilization using finite element method
چکیده انگلیسی

Determination of heat transfer and temperature profile during freezing step is fundamental to predict the final structure of a lyophilized product. The aim of this study was to develop and optimize a dynamic model based on finite element method for simulation of freezing step in order to study final product morphology in both vertical and radial directions. Different factors have been taken into account: chamber pressure, shelf temperature, vial shape, initial solution temperature, nucleation temperature and phase changes. The dynamic axisymmetric model proposed could simulate temperature of each point in the vial and position of liquid–solid interface, without necessity of fitting parameters or questionable assumptions. In addition, the model was extended to predict the average crystal size in each element and the influence of different factors was examined.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computers & Chemical Engineering - Volume 35, Issue 11, 15 November 2011, Pages 2274–2283
نویسندگان
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