کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
173958 458619 2007 18 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Addressing the challenges of multiscale model management in systems biology
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Addressing the challenges of multiscale model management in systems biology
چکیده انگلیسی

Mathematical and computational modelling are emerging as important techniques for studying the behaviour of complex biological systems. We argue that two advances are necessary to properly leverage these techniques: firstly, the ability to integrate models developed and executed on separate tools, without the need for substantial translation and secondly, a comprehensive system for storing and man-ageing not only the models themselves but also the parameters and tools used to execute those models and the results they produce. A framework for modelling with these features is described here. We have developed of a suite of XML-based services used for the storing and analysis of models, model parameters and results, and tools for model integration. We present these here, and evaluate their effectiveness using a worked example based on part of the hepatocyte glycogenolysis system.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computers & Chemical Engineering - Volume 31, Issue 8, 15 August 2007, Pages 962–979
نویسندگان
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