کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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173958 | 458619 | 2007 | 18 صفحه PDF | دانلود رایگان |

Mathematical and computational modelling are emerging as important techniques for studying the behaviour of complex biological systems. We argue that two advances are necessary to properly leverage these techniques: firstly, the ability to integrate models developed and executed on separate tools, without the need for substantial translation and secondly, a comprehensive system for storing and man-ageing not only the models themselves but also the parameters and tools used to execute those models and the results they produce. A framework for modelling with these features is described here. We have developed of a suite of XML-based services used for the storing and analysis of models, model parameters and results, and tools for model integration. We present these here, and evaluate their effectiveness using a worked example based on part of the hepatocyte glycogenolysis system.
Journal: Computers & Chemical Engineering - Volume 31, Issue 8, 15 August 2007, Pages 962–979