کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1905474 | 1534717 | 2009 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Intrabody and Parkinson's disease Intrabody and Parkinson's disease](/preview/png/1905474.png)
The intrabody technology has become a promising therapeutic avenue for a variety of incurable diseases. This technology is an intracellular application of gene-engineered antibodies, aimed at ablating the abnormal function of intracellular molecules. Parkinson's disease (PD) is a common neurodegenerative disease with no cure. Recent studies have explored possible intrabody applications against alpha-synuclein (α-syn), whose misfolding is believed to cause a familial form of PD. Here, we review the origin, production, and therapeutic mechanisms of intrabodies and the potential of intrabody protection against α-syn toxicity. Furthermore, we propose possible intrabody applications against leucine-rich repeat kinase 2 (LRRK2), whose mutations are the most frequent known cause of familial and sporadic PD.
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1792, Issue 7, July 2009, Pages 634–642