Effect of shear stress, statins and TNF-α on hemostatic genes in human endothelial cells

► We examined the non-lipid lowering effects of statins in endothelial cells. ► Combinatory effects of shear stress, statins, TNF-α on hemostatic genes were studied. ► Statins have anti-inflammatory effects counteracting the effect of TNF-α. ► Statins have endothelial protective properties against unfavorable flow profiles. ► Time to reconsider the therapeutic window of statins?