کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1930444 1050515 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Angiotensin II induced catabolic effect and muscle atrophy are redox dependent
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Angiotensin II induced catabolic effect and muscle atrophy are redox dependent
چکیده انگلیسی

Angiotensin II (Ang II) causes skeletal muscle wasting via an increase in muscle catabolism. To determine whether the wasting effects of Ang II were related to its ability to increase NADPH oxidase-derived reactive oxygen species (ROS) we infused wild-type C57BL/6J or p47phox−/− mice with vehicle or Ang II for 7 days. Superoxide production was increased 2.4-fold in the skeletal muscle of Ang II infused mice, and this increase was prevented in p47phox−/− mice. Apocynin treatment prevented Ang II-induced superoxide production in skeletal muscle, consistent with Ang II increasing NADPH oxidase derived ROS. Ang II induced loss of body and skeletal muscle weight in C57BL/6J mice, whereas the reduction was significantly attenuated in p47phox−/− animals. The reduction of skeletal muscle weight caused by Ang II was associated with an increase of proteasome activity, and this increase was completely prevented in the skeletal muscle of p47phox−/− mice. In conclusion, Ang II-induced skeletal muscle wasting is in part dependent on NADPH oxidase derived ROS.


► Angiotensin II increases NADPH oxidase-derived ROS in skeletal muscle.
► Deletion of p47phox prevents Ang II-induced skeletal muscle weight loss.
► Ang II-induced proteasome activity in skeletal muscle is prevented in p47phox−/− mice.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 409, Issue 2, 3 June 2011, Pages 217–221
نویسندگان
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