Formation of distinct inclusion bodies by inhibition of ubiquitin-proteasome and autophagy-lysosome pathways

► Distinct inclusion bodies are developed by inhibition of UPP and ALP. ► The inclusion bodies differ in morphology, localization and formation process. ► The inclusion bodies are distinguishable by the localization of TSC2. ► Inhibition of both UPP and ALP simultaneously induces those inclusion bodies.