Autophagy delivers misfolded secretory proteins accumulated in endoplasmic reticulum to vacuoles in the filamentous fungus Aspergillus oryzae

► Misfolded secretory proteins accumulate in endoplasmic reticulum (ER). ► We investigate the fate of misfolded secretory proteins in Aspergillus oryzae. ► Misfolded secretory proteins accumulated in ER are subsequently delivered to vacuole. ► The protein delivery to vacuole does not occur in the absence of autophagic activity. ► Autophagy delivers misfolded secretory proteins accumulated in ER to vacuole.