کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1937713 1050724 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reduced response of splenocytes after mitogen-stimulation in the prion protein (PrP) gene-deficient mouse: PrPLP/Doppel production and cerebral degeneration
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Reduced response of splenocytes after mitogen-stimulation in the prion protein (PrP) gene-deficient mouse: PrPLP/Doppel production and cerebral degeneration
چکیده انگلیسی

Splenocytes of wild-type (Prnp+/+) and prion protein gene-deficient (Prnp−/−) mice were treated with various activation stimuli such as T cell mitogen concanavalin A (ConA), phorbol 12-myristate 13-acetate (PMA) + ionomycin (Io), or B cell mitogen lipopolysaccharide (LPS). Cellular prion protein (PrPC) expression was enhanced following ConA stimulation, but not PMA + Io or LPS in Prnp+/+ splenocytes. Rikn Prnp−/− splenocytes elicited lower cell proliferations than Prnp+/+ or Zrch I Prnp−/− splenocytes after LPS stimulation and showed sporadic nerve cells in the cerebral cortex and deeper structure. Around the degenerated nerve cells, mild vacuolation in the neuropil was observed. This neural alteration correlated well to the suppressed response of B cells in the spleen. The finding that discrete lesions within the central nervous systems induced marked modulation of immune function probably indicates the existence of a delicately balanced neural-endocrine network by PrPC and PrPLP/Doppel.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 358, Issue 2, 29 June 2007, Pages 469–474
نویسندگان
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