کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1946660 | 1054262 | 2011 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: A chromatin perspective of plant cell cycle progression A chromatin perspective of plant cell cycle progression](/preview/png/1946660.png)
The finely regulated series of events that span from the birth of a cell to the production of two new born cells encompass the cell cycle. Cell cycle progression occurs in a unidirectional manner and requires passing through a number of stages in response to cellular, developmental and environmental cues. In addition to these signaling cascades, transcriptional regulation plays a major role and acts coordinately with genome duplication during S-phase and chromosome segregation during mitosis. In this context, chromatin is revealing as a highly dynamic and major player in cell cycle regulation not only owing to the changes that occur as a consequence of cell cycle progression but also because some specific chromatin modifications are crucial to move across the cell cycle. These are particularly relevant for controlling transcriptional activation and repression as well as initiation of DNA replication and chromosome compaction. As a consequence the epigenetic landscape of a proliferating cell is very complex throughout the cell cycle. These aspects of chromatin dynamics together with the impact of epigenetic modifications on cell proliferation will be discussed in this article. This article is part of a Special Issue entitled: Epigenetic Control of cellular and developmental processes in plants.
Research highlights
► Chromatin is revealing as highly dynamic during cell cycle progression.
► Specific chromatin modifications are crucial to move across the cell cycle.
► These refer to transcriptional control, genome duplication and chromsome compaction.
► The epigenetic landscape of a proliferating cell is very complex.
Journal: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms - Volume 1809, Issue 8, August 2011, Pages 379–387