Transcription factor GABP/NRF-2 controlling biogenesis of mitochondria regulates basal expression of peroxiredoxin V but the mitochondrial function of peroxiredoxin V is dispensable in the dog

► Basal expression of the hPRDX5 gene is regulated by transcription factor GABP/NRF-2. ► Canis familiaris PRDX5 does not contain a mitochondrial targeting sequence. ► Canis familiaris PRDX5 does not target mitochondria.