کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1978447 | 1061551 | 2007 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of alkylphenols on glycerophospholipids and cholesterol in liver and brain from female Atlantic cod (Gadus morhua)
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کلمات کلیدی
MAGButylphenolELSDdichlorodiphenyltrichloroethaneERODCYP1ASFAMUFAmonoacylglycerolPAHAPEFFABHT17 β-Estradiol - 17 β-اترادیولAlkylphenols - آلکیل فنول هاAlkylphenol - آلکیلفنولAlkylphenol ethoxylates - اتوکسیلات های آلکیلفنولFatty acid - اسید چربPolyunsaturated fatty acids - اسید چرب اشباع نشدهPUFA - اسید چرب چند غیراشباعFree fatty acids - اسیدهای چرب آِزادsaturated fatty acids - اسیدهای چرب اشباع شدهmonounsaturated fatty acids - اسیدهای چرب غیر اشباعAtlantic cod - اقیانوس اطلسOctylphenol - اکتیلفنولtriacylglycerol - تری آسیل گلیسرول TAG یا triacylglycerols - تری گلیسرید یا تری آسیل گلیسرولEvaporative light-scattering detection - تشخیص پراکندگی نور تبخیریdiacylglycerol - دیسیل گلیسیرینDDT - دیکرو دیفنیل تری کلرواتانDAG - روزCytochrome P4501A - سیتوکروم P4501Aphosphatidylinositol - فسفاتیدیل اینوزیتولphosphatidylcholine - فسفاتیدیل کولینphosphatidylethanolamine - فسفاتیدیلتانولامینPhosphatidylserine - فسفاتیدیلسرینLipid - لیپیدPolar lipids - لیپید های قطبیfatty acid methyl esters - متیل استرهای اسید چربFAME یا fatty acid methyl esters - متیل استرهای اسید چربNonylphenol - نونیل فنولPolyaromatic hydrocarbons - هیدروکربنهای Polyaromaticbutylated hydroxytoluene - هیدروکسی تورولین باتلاقیcholesterol - کلسترول
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Offshore oil production releases large amounts of lipophilic compounds in produced water into the ocean. In 2004, 143 million m3 produced water, containing approximately 13 tons of long-chain (> C4) alkylphenols (AP), was discharged from installations in the Norwegian sector of the North Sea. Long-chain APs are known to cause endocrine disruption in a number of species. However, relatively little is known about their long-term effects in the marine environment. In the present study, Atlantic cod (Gadus morhua) were exposed (0.02 to 80 mg AP/kg) to a mixture (1:1:1:1) of APs (4-tert-butylphenol, 4-n-pentylphenol, 4-n-hexylphenol and 4-n-heptylphenol) or 17 β-estradiol (5 mg E2/kg) for 5 weeks and the effect on the fatty acid profile and cholesterol content in the membrane lipids from the liver and the brain was studied. We also determined the interaction between different para-substituted APs and glycerophospholipids (native phospholipids extracted from cod liver and brain) and model phosphatidylcholine (PC 16:0/22:6 n-3) in monolayers with the Langmuir-Blodget technique. The study demonstrated that APs and E2 alter the fatty acid profile in the polar lipids (PL) from the liver to contain more saturated fatty acids (SFA) and less n-3 polyunsaturated fatty acids (n-3 PUFA) compared with control. In the brain of the exposed groups a similar effect was demonstrated, although with higher saturation of the fatty acids found in the neutral lipids (mainly cholesterol ester), but not in the polar lipids. The AP and E2 exposure also gave a decline in the cholesterol levels in the brain. The in vitro studies showed that APs increased the mean molecular areas of the PLs in the monolayers at concentrations down to 5 μM, most likely due to intercalation of the APs between PL molecules. The increase in molecular area increased with the length of the alkyl side chain.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology - Volume 145, Issue 3, April 2007, Pages 420-430
Journal: Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology - Volume 145, Issue 3, April 2007, Pages 420-430
نویسندگان
Sonnich Meier, Thorny Cesilie Andersen, Kristin Lind-Larsen, Asbjørn Svardal, Holm Holmsen,