کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2022920 | 1542429 | 2009 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Targeting the ghrelin receptor to regulate food intake
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کلمات کلیدی
CREBOrexigenicGHS-RCPT-1UCP2pro-opiomelanocortinCARTVTASFOPOMCAgRPNPYAMPKPWSAMP-activated protein kinase - AMP-پروتئین کیناز فعال شده استROS - ROSγ-aminobutyric acid - اسید γ-آمینوبوتیریکGoat - بزcocaine- and amphetamine-regulated transcript - دستورالعمل تنظیم شده کوکائین و آمفتامینPrader-Willi syndrome - سندرم Prader-Williarea postrema - طبقه آخرSubfornical organ - عضو زیربنیکیArc - قوسfood intake - مصرف غذاventral tegmental area - ناحیه تگمنتوم شکمیarcuate nucleus - هسته قوسGrowth hormone - هورمون رشدEnergy homeostasis - هومئوستاز انرژیbody weight - وزن بدنcAMP responsive element binding protein - پروتئین اتصال دهنده عنصر پاسخ دهنده cAMPuncoupling protein 2 - پروتئین جدا سازی 2agouti-related peptide - پپتید مرتبط با agoutiadiposity - چاقیGABA - گاباGhrelin - گرلینGhrelin O-acyltransferase - گرلین O-acyltransferaseReactive oxygen species - گونههای فعال اکسیژنgrowth hormone secretagogue receptor - گیرنده ترشح هورمون رشدNeuropeptide Y - یوروپروتئین Y
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
The increasing prevalence of obesity and the obesity-associated morbidities represent one of the major health problems of the western society. This has renewed interest in our understanding of factors that control appetite. The 28 amino acid peptide may represent one of the key players in the regulation of food intake since it is the only circulating orexigenic peptide. Ghrelin not only acts as a hunger signal but also as an adiposity signal. These effects are influenced by the internal energy status and can be considered as homeostatic signals. In addition ghrelin has direct effects on components of the reward system and increases the appetitive value of food. This hedonic feeding behavior of ghrelin can be considered as a non-homeostatic signal as it occurs in the absence of nutritional or caloric deficiency. In this review we address how these signals, elicited by ghrelin, can powerfully augment the drive to eat. Better understanding of the mechanisms by which ghrelin exerts its effect may enable the development of new treatments for obesity but also for conditions of cachexia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Peptides - Volume 156, Issues 1â3, 7 August 2009, Pages 13-23
Journal: Regulatory Peptides - Volume 156, Issues 1â3, 7 August 2009, Pages 13-23
نویسندگان
Inge Depoortere,