کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2131608 | 1086649 | 2009 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
WAFL, a new protein involved in regulation of early endocytic transport at the intersection of actin and microtubule dynamics
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کلمات کلیدی
WASPIBDFKPBEndocytosis - آندوسیتوز یا درون بریactin - اکتین Crohn's disease - بیماری کرونInflammatory bowel disease - بیماریهای التهابی رودهTransport - حمل و نقل یا ترابریMicrotubules - میکروتوبول، ریزلوله هاwip - پاک کردنFK506-binding protein - پروتئین اتصال دهنده FK506WASP-interacting protein - پروتئین تعامل WASPWiskott–Aldrich syndrome protein - پروتئین سندرم Wiskott-AldrichUlcerative colitis - کولیت اولسراتیو
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: WAFL, a new protein involved in regulation of early endocytic transport at the intersection of actin and microtubule dynamics WAFL, a new protein involved in regulation of early endocytic transport at the intersection of actin and microtubule dynamics](/preview/png/2131608.png)
چکیده انگلیسی
We have previously identified a new gene with sequence homology to the WASP-family of actin regulators denoted WAFL (WASP and FKBP-like). Here we report a possible biological function for WAFL, by demonstrating an association to early endosomes via its central coiled-coil domain. Further we show by functional and structural studies that WAFL is associated with both microtubules and the actin filament system, the two means of transport of early endosomes. In addition, WAFL interacts with WASP-interacting protein (WIP) and actin, thus linking WAFL to actin dynamics. The use of RNAi depletion of WAFL shows that WAFL-deficient cells display delayed transport of endosomal cargo. Our findings are compatible with a model whereby WAFL is involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Cell Research - Volume 315, Issue 6, 1 April 2009, Pages 1040-1052
Journal: Experimental Cell Research - Volume 315, Issue 6, 1 April 2009, Pages 1040-1052
نویسندگان
Ing-Marie Viklund, Pontus Aspenström, Vannary Meas-Yedid, Bo Zhang, Jolanta Kopec, Daniel Ã
gren, Gunter Schneider, Mauro D'Amato, Jean-Christophe Olivo-Marin, Philippe Sansonetti, Guy Tran Van Nhieu, Sven Pettersson,