کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2132976 1086731 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reversible, activity-dependent targeting of profilin to neuronal nuclei
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Reversible, activity-dependent targeting of profilin to neuronal nuclei
چکیده انگلیسی

The actin cytoskeleton in pyramidal neurons plays a major role in activity-dependent processes underlying neuronal plasticity. The small actin-binding protein profilin shows NMDA receptor-dependent accumulation in dendritic spines, which is correlated with suppression of actin dynamics and long-term stabilization of synaptic morphology. Here we show that following NMDA receptor activation profilin also accumulates in the nucleus of hippocampal neurons via a process involving rearrangement of the actin cytoskeleton. This simultaneous targeting to dendritic spines and the cell nucleus suggests a novel mechanism of neuronal plasticity in which profilin both tags activated synapses and influences nuclear events.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Cell Research - Volume 312, Issue 12, 15 July 2006, Pages 2279–2287
نویسندگان
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