کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2402920 1102868 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Epidemiology of invasive pneumococcal infection among hospitalized children aged less than 5 years in Oman
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Epidemiology of invasive pneumococcal infection among hospitalized children aged less than 5 years in Oman
چکیده انگلیسی

The objective of this study was to describe the epidemiology of invasive pneumococcal disease (IPD) in Omani children. We retrospectively reviewed cases admitted in children <5 years of age who were admitted in one of 4 tertiary care facilities within the Muscat Governorate. These cases represented nearly 95% of all IPD admissions recorded throughout the country from 1 January 2006 to 31 December 2006. Cases of IPD were identified using the ICD-10 discharge code. Case definition required microbiological confirmation (i.e., isolation of Streptococcus pneumoniae from blood, cerebrospinal fluid or any other normally sterile biological fluid) or clinical diagnosis in the absence of a specimen. A total of 41 cases of IPD were identified. The annual incidence of IPD was 26.1 per 100,000 in children <2 years old and 18.6 per 100,000 in children <5 years old. Among the reported IPD cases, 22 (54%) isolates were resistant to at least one antibiotic and 15 (37%) of patients had a known comorbid medical condition. These results demonstrate that the incidence of IPD in Oman during 2006 was high compared to many of the neighboring countries and provides baseline data on the incidence of IPD in an era before the introduction of the pneumococcal conjugate vaccine (PCV). In light of evidence for a significant incidence of IPD, we recommended that a nationwide surveillance system be put in place to monitor the incidence of IPD in children <5 years of age in Oman and to document the impact of PCV.


► S. pneumoniae is a significant cause of invasive pneumococcal diseases (IPD), which can be fatal.
► Few studies have reported IPD incidence in children in Oman.
► Annual IPD incidence was 26.1/100,000 in children <2 years and 18.6/100,000 in children <5 years, high vs. many other countries.
► We recommend a nationwide surveillance system to monitor the incidence of IPD in children in Oman.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 30, Supplement 6, 31 December 2012, Pages G7–G10
نویسندگان
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