کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2404021 1102947 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of influenza vaccination on hospitalizations in persons aged 50 years and older
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Effect of influenza vaccination on hospitalizations in persons aged 50 years and older
چکیده انگلیسی

ObjectiveTo estimate influenza vaccine effectiveness (VE) in preventing hospitalizations in persons over 50 years of age.DesignWe performed a retrospective, population based study, using a “difference-in-differences” approach to determine the association between hospitalization and prior vaccination. We examined this association when influenza was not circulating and compared it to the association found when influenza was circulating. VE was estimated from the difference in the association between hospitalization and prior vaccination, inside vs. outside influenza seasons.SettingKaiser Permanente in Northern California.PatientsHealth plan members aged 50 years and older during the September 1997 to August 2008 study period, when there were about 68,000 pneumonia hospitalizations in 10 million person-years.ResultsVaccination was associated with lower risk of hospitalization for pneumonia and influenza, even before flu season, presumably due to unmeasured confounders. When influenza arrived the hospitalization-vaccination association strengthened, yielding an adjusted VE estimate of 12.4% (95% CI: 1.6–22.0) in persons aged 50–64, and 8.5% (95% CI: 3.3–13.5) in those aged 65 years and older. There was no significant effect on hospitalizations for ischemic heart disease (IHD), congestive heart failure (CHF), cerebrovascular disease (CVD), or trauma.ConclusionsInfluenza vaccination has a modest but significant effect on prevention of hospitalization for pneumonia and influenza in persons 50 years of age and older.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 28, Issue 45, 21 October 2010, Pages 7267–7272
نویسندگان
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