کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2404362 | 1102971 | 2010 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Thermostable formulations of a hepatitis B vaccine and a meningitis A polysaccharide conjugate vaccine produced by a spray drying method Thermostable formulations of a hepatitis B vaccine and a meningitis A polysaccharide conjugate vaccine produced by a spray drying method](/preview/png/2404362.png)
Thermostable vaccines promise to simplify the logistics of vaccine distribution and expand the immunization coverage. In this study, a pilot-scale spray drying process was developed and used to produce glassy state formulations of a recombinant hepatitis B (HepB) vaccine containing aluminum adjuvant and Neisseria meningitidis A (MenA) protein–polysaccharide conjugate vaccine, representing two common types of subunit vaccines in use today: the spray-dried HepB vaccine formulations were stable for at least 24 months at 37 °C while several MenA vaccine formulations exhibited complete stability at temperatures up to 60 °C. This study demonstrates the feasibility of producing thermostable vaccines with advanced processing and formulation technologies.
Journal: Vaccine - Volume 28, Issue 31, 12 July 2010, Pages 5093–5099