کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2404995 1103009 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Characterization of proteins Msp22 and Msp75 as vaccine antigens of Moraxella catarrhalis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Characterization of proteins Msp22 and Msp75 as vaccine antigens of Moraxella catarrhalis
چکیده انگلیسی

Moraxella catarrhalis is a respiratory tract pathogen causing otitis media in children and respiratory tract infections in adults with chronic obstructive pulmonary disease. This study examined two newly identified proteins as potential vaccine antigens. Antisera raised to recombinant purified proteins Msp22 and Msp75 recognized corresponding native proteins in multiple strains of M. catarrhalis. Vaccine formulations individually administered subcutaneously and intranasally showed enhanced clearance of M. catarrhalis in a mouse pulmonary clearance model by both routes of administration. Msp22 and Msp75 are antigenically conserved proteins that induce potentially protective immune responses and should be examined further as vaccine antigens for M. catarrhalis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 27, Issue 50, 23 November 2009, Pages 7065–7072
نویسندگان
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