کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2409247 | 1103214 | 2007 | 5 صفحه PDF | دانلود رایگان |

Current guidelines recommend up to two doses of the pneumococcal conjugate heptavalent vaccine (PCV-7) in children up to 5 years old followed by and a dose of the polysaccharide vaccine (PPV-23) for patients over 2 years old to broaden serotype immunity. We assessed the serotype responses to two doses of PCV-7 and a dose of PPV-23 in a cohort of children in the 2–16-year age range in order to determine whether PPV-23 induced effective immunity to non-PCV-7 serotypes. Pneumococcal antibody concentrations to the seven serotypes covered by PCV-7 and five additional serotypes covered by PPV-23 but not PCV-7 were measured in 60 children aged 2–16 years. None of the children had a primary antibody immunodeficiency. Vaccinated children had 7–30-fold higher antibody concentrations than unvaccinated children to all serotypes contained in the PCV-7 (P < 0.001). In contrast, serotypes covered by the PPV-23 but not PCV-7 were only one- to two-fold higher and there was no significant increase in the number of children who had protective concentrations of antibody (≥0.35 mcg/ml) against these serotypes. In this cohort of children, PPV-23 vaccine did not broaden the protection in vitro against potentially pathogenic strains of Streptococcus pneumoniae. We call into question the recommendation to use the PPV-23 in children.
Journal: Vaccine - Volume 25, Issue 34, 21 August 2007, Pages 6321–6325