New genetic mechanism, origin and population dynamic of bovine ephemeral fever virus

• A novel East Asia BEFV with a unique mosaic G gene is isolated.
• A new genetic mechanism of BEFV was found.
• The prevailing BEFV might originate from Africa before 100 years.
• Today, there is a highest risk of BEF outbreak in the world.

Bovine ephemeral fever virus (BEFV) is a typical species of the genusEphemerovirus in the family Rhabdoviridae. Today, prevailing BEFV can be divided into three phylogeographic lineages, East Asia, Mideast, and Australia. In this study, we provide evidence that the whole East Asia lineage originates from a homologous recombination (HR) between the Mideast and Australia lineages that probably occurred in the 1940s. To our knowledge, HR has not been proposed before as the genetic mechanism of BEFV. According to the HR event and Bayesian estimation, the three BEFV lineages might originate from Africa, and may have spread to Asia and Australia through the Mideast. In addition, the population of the virus may have augmented significantly in the 2000s, suggesting that the risk for outbreaks of BEFV may be high at present.