کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2485058 | 1114344 | 2012 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Transport of a Lipophilic Ionizable Permeant (Capric Acid) Across a Lipophilic Membrane (Silicone Polymer Membrane) from Aqueous Buffered Solutions in the Presence of Hydroxypropyl-β-Cyclodextrin
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Transport of a Lipophilic Ionizable Permeant (Capric Acid) Across a Lipophilic Membrane (Silicone Polymer Membrane) from Aqueous Buffered Solutions in the Presence of Hydroxypropyl-β-Cyclodextrin Transport of a Lipophilic Ionizable Permeant (Capric Acid) Across a Lipophilic Membrane (Silicone Polymer Membrane) from Aqueous Buffered Solutions in the Presence of Hydroxypropyl-β-Cyclodextrin](/preview/png/2485058.png)
چکیده انگلیسی
The present study describes a physical model approach applicable to understanding the transport of highly lipophilic, ionizable drugs across a lipophilic membrane between two aqueous compartments in the presence of a cyclodextrin in the aqueous phase. Model predictions were compared with experimental results of capric acid (HA) transport across a silicone polymer membrane in the presence and in the absence of 2-hydroxypropyl-β-cyclodextrin (HPB) in the aqueous phase over wide ranges of conditions. Key parameters entering into the physical model calculations were the HA-HPB and the Aâ-HPB binding constants, the unionized and ionized free and the complexed HA species diffusion coefficients, the HA pKa, the HA intrinsic silicone polymer membrane permeability coefficient, and the aqueous boundary layer thickness. All of these key parameters were determined from independent or essentially independent experiments. The agreement between the model predictions and the experiments were generally quite good over the entire ranges of the studied independent variables. The results of this study provide an approach that is useful in the mechanistic understanding of how cyclodextrins may enhance the passive absorption of highly lipophilic, low solubility drug molecules in the intestinal tract.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 101, Issue 7, July 2012, Pages 2340-2352
Journal: Journal of Pharmaceutical Sciences - Volume 101, Issue 7, July 2012, Pages 2340-2352
نویسندگان
Richard V. Hymas, Norman F.H. Ho, William I. Higuchi,