کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2485524 | 1114357 | 2008 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Studies on the Crystal forms of Pefloxacin: Preparation, Characterization, and Dissolution Profile
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Different crystal forms of pefloxacin were prepared using solvents of varying polarity. X-ray diffractometry (XRD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), infrared absorption spectroscopy (FT-IR), melting point, microcalorimetry and in vitro dissolution rate studies were conducted to investigate various characterstics of different crystalline forms of the pefloxacin. Five different polymorphs of pefloxacin have been identified on the basis of instrumental techniques. The polymorphs differed in their dissolution profile and all of them showed unusual behavior of highest dissolution in the first 15Â min. The rate of dissolution went on decreasing and got stabilized to a constant value after 4Â h.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 97, Issue 7, July 2008, Pages 2637-2648
Journal: Journal of Pharmaceutical Sciences - Volume 97, Issue 7, July 2008, Pages 2637-2648
نویسندگان
Mange Ram Yadav, Anwar R. Shaikh, V. Ganesan, Rajani Giridhar, Renu Chadha,