کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2485524 1114357 2008 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Studies on the Crystal forms of Pefloxacin: Preparation, Characterization, and Dissolution Profile
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Studies on the Crystal forms of Pefloxacin: Preparation, Characterization, and Dissolution Profile
چکیده انگلیسی
Different crystal forms of pefloxacin were prepared using solvents of varying polarity. X-ray diffractometry (XRD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), infrared absorption spectroscopy (FT-IR), melting point, microcalorimetry and in vitro dissolution rate studies were conducted to investigate various characterstics of different crystalline forms of the pefloxacin. Five different polymorphs of pefloxacin have been identified on the basis of instrumental techniques. The polymorphs differed in their dissolution profile and all of them showed unusual behavior of highest dissolution in the first 15 min. The rate of dissolution went on decreasing and got stabilized to a constant value after 4 h.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 97, Issue 7, July 2008, Pages 2637-2648
نویسندگان
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