کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2486066 | 1114374 | 2010 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Fusion processing of itraconazole solid dispersions by kinetisol® dispersing: A comparative study to hot melt extrusion
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Fusion processing of itraconazole solid dispersions by kinetisol® dispersing: A comparative study to hot melt extrusion Fusion processing of itraconazole solid dispersions by kinetisol® dispersing: A comparative study to hot melt extrusion](/preview/png/2486066.png)
چکیده انگلیسی
KinetiSol® Dispersing (KSD) is a novel high energy manufacturing process investigated here for the production of pharmaceutical solid dispersions. Solid dispersions of itraconazole (ITZ) and hypromellose were produced by KSD and compared to identical formulations produced by hot melt extrusion (HME). Materials were characterized for solid state properties by modulated differential scanning calorimetry and Xâray diffraction. Dissolution behavior was studied under supersaturated conditions. Oral bioavailability was determined using a Sprague-Dawley rat model. Results showed that KSD was able to produce amorphous solid dispersions in under 15âs while production by HME required over 300âs. Dispersions produced by KSD exhibited single phase solid state behavior indicated by a single glass transition temperature (Tg) whereas compositions produced by HME exhibited two Tgs. Increased dissolution rates for compositions manufactured by KSD were also observed compared to HME processed material. Near complete supersaturation was observed for solid dispersions produced by either manufacturing processes. Oral bioavailability from both processes showed enhanced AUC compared to crystalline ITZ. Based on the results presented from this study, KSD was shown to be a viable manufacturing process for the production of pharmaceutical solid dispersions, providing benefits over conventional techniques including: enhanced mixing for improved homogeneity and reduced processing times. © 2009 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 99: 1239-1253, 2010
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 99, Issue 3, March 2010, Pages 1239-1253
Journal: Journal of Pharmaceutical Sciences - Volume 99, Issue 3, March 2010, Pages 1239-1253
نویسندگان
James C. DiNunzio, Chris Brough, Dave A. Miller, Robert O. III, James W. McGinity,