کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2486143 1556514 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Physicochemical stability of solid dispersions of enantiomeric or racemic ibuprofen in stearic acid
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Physicochemical stability of solid dispersions of enantiomeric or racemic ibuprofen in stearic acid
چکیده انگلیسی
The aim of this study was to investigate the solid dispersion phase behavior of s‐ or rs‐ibuprofen in stearic acid. By means of thermal analysis, we have demonstrated the total immiscibility, in solid state, of the corresponding binary mixtures. This indicates that no specific interactions exist between the chosen excipient and active pharmaceutical ingredient (API) that lead to eutectic systems. Furthermore, based on calorimetric and X‐ray diffraction experiments, we have showed that upon cooling of the molten state, only stearic acid recrystallizes in the presence of s‐ibuprofen, whereas a quaternary phase mixture is obtained for the racemic ibuprofen/stearic acid preparation. The solubility of stearic acid in s‐ibuprofen liquid in all proportions was also determined. Overall, the results presented here offer an approach for the study of API/excipient interactions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 100, Issue 12, December 2011, Pages 5235-5243
نویسندگان
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