کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2486281 | 1114379 | 2010 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Complexation of Sulfonamides With β-Cyclodextrin Studied by Experimental and Theoretical Methods
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
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چکیده انگلیسی
The complex formation between three structurally related sulfonamides (sulfadiazine (SDZ), sulfamerazine (SMR), and sulfamethazine (SMT)) and β-cyclodextrin (β-CD) was studied, by exploring its structure affinity relationship. In all the cases, 1:1 stoichiometries were determined with different relative affinities found by phase solubility (SDZ:β-CD > SMR:β-CD > SMT:β-CD) and nuclear magnetic resonance (NMR) (SMT:β-CD > SMR:β-CD > SDZ:β-CD) studies. The spatial configurations determined by NMR were in agreement with those obtained by molecular modeling, showing that SDZ included its aniline ring into β-CD, while SMR and SMT included the substituted pyrimidine ring. Energetic analyses demonstrated that hydrophobicity is the main driving force to complex formation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 99, Issue 7, July 2010, Pages 3166-3176
Journal: Journal of Pharmaceutical Sciences - Volume 99, Issue 7, July 2010, Pages 3166-3176
نویسندگان
Ariana Zoppi, Mario A. Quevedo, Alicia Delrivo, Marcela R. Longhi,