کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2486340 1114381 2011 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nitrofurantoin-p‐aminobenzoic acid cocrystal: Hydration stability and dissolution rate studies
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Nitrofurantoin-p‐aminobenzoic acid cocrystal: Hydration stability and dissolution rate studies
چکیده انگلیسی
Nitrofurantoin (NF) drug is known to transform to a hydrate form in aqueous medium. The hydration stability and dissolution rate of a few cocrystals of NF were compared with that of its stable β polymorph and hydrate form II. Hydrogen bonding and molecular packing in the novel cocrystal structures were analyzed. Pharmaceutical cocrystals of NF with p‐aminobenzoic acid (PABA) and urea showed superior physicochemical properties compared with the known l‐arginine salt hydrate. All the solid‐state adducts were characterized by single‐crystal X‐ray diffraction, X‐ray powder diffraction, differential scanning calorimetry, and thermogravimetric analysis. NF-PABA cocrystal was found to be superior among the compounds studied in terms of minimal transformation to NF hydrate and comparable dissolution rate to the reference drug. © 2011 Wiley‐Liss, Inc. and the American Pharmacists Association J Pharm Sci 100:3233-3244, 2011
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 100, Issue 8, August 2011, Pages 3233-3244
نویسندگان
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