کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2486340 | 1114381 | 2011 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Nitrofurantoin-pâaminobenzoic acid cocrystal: Hydration stability and dissolution rate studies
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
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چکیده انگلیسی
Nitrofurantoin (NF) drug is known to transform to a hydrate form in aqueous medium. The hydration stability and dissolution rate of a few cocrystals of NF were compared with that of its stable β polymorph and hydrate form II. Hydrogen bonding and molecular packing in the novel cocrystal structures were analyzed. Pharmaceutical cocrystals of NF with pâaminobenzoic acid (PABA) and urea showed superior physicochemical properties compared with the known lâarginine salt hydrate. All the solidâstate adducts were characterized by singleâcrystal Xâray diffraction, Xâray powder diffraction, differential scanning calorimetry, and thermogravimetric analysis. NF-PABA cocrystal was found to be superior among the compounds studied in terms of minimal transformation to NF hydrate and comparable dissolution rate to the reference drug. © 2011 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 100:3233-3244, 2011
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 100, Issue 8, August 2011, Pages 3233-3244
Journal: Journal of Pharmaceutical Sciences - Volume 100, Issue 8, August 2011, Pages 3233-3244
نویسندگان
Suryanarayan Cherukuvada, N. Jagadeesh Babu, Ashwini Nangia,