کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2487466 | 1114418 | 2008 | 33 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Intraâarticular depot formulation principles: Role in the management of postoperative pain and arthritic disorders
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
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چکیده انگلیسی
The joint cavity constitutes a discrete anatomical compartment that allows for local drug action after intraâarticular injection. Drug delivery systems providing local prolonged drug action are warranted in the management of postoperative pain and not least arthritic disorders such as osteoarthritis. The present review surveys various themes related to the accomplishment of the correct timing of the events leading to optimal drug action in the joint space over a desired time period. This includes a brief account on (patho)physiological conditions and novel potential drug targets (and their location within the synovial space). Particular emphasis is paid to (i) the potential feasibility of various depot formulation principles for the intraâarticular route of administration including their manufacture, drug release characteristics and in vivo fate, and (ii) how release, mass transfer and equilibrium processes may affect the intraâarticular residence time and concentration of the active species at the ultimate receptor site.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 97, Issue 11, November 2008, Pages 4622-4654
Journal: Journal of Pharmaceutical Sciences - Volume 97, Issue 11, November 2008, Pages 4622-4654
نویسندگان
Claus Larsen, Jesper Ãstergaard, Susan W. Larsen, Henrik Jensen, Stine Jacobsen, Casper Lindegaard, Pia H. Andersen,