کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2487476 | 1114418 | 2008 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ethyl-paraben and nicotinamide mixtures: Apparent solubility, thermal behavior and X-ray structure of the 1:1 co-crystal
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
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چکیده انگلیسی
This work aims at investigating the nicotinamide (NA)-ethylâparaben (EP) binary system both in solution and in the solid state. In particular, the apparent EP solubility in water was studied in the presence of different NA concentrations (between 0.28 and 1.64 M). It was found that the apparent EP solubility increase (nearly twofold) observed at the highest NA concentration tested can be ascribed to a change in the polarity of the solvent mixture, rather than to a direct effect of NA on EP. The effect of fusion and reâcrystallization from water or ethanol solutions on EP and NA mixtures was investigated by means of differential scanning calorimetry, elemental analysis and Xâray diffraction both on powder and single crystal. It was discovered that EP and NA form a coâcrystal having a 1:1 molar composition that can be easily crystallized from ethanol. Single crystal Xâray analysis of this species revealed that the NA and EP molecules form corrugated layers within which the two components are intimately associated by a dense network of hydrogen bonds. In the presence of an excess NA in solution, the EPâNA coâcrystal has lower water solubility with respect to both the single coâcrystal formers and precipitates in aqueous solutions at ambient temperature. © 2008 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 97:4830-4839, 2008
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 97, Issue 11, November 2008, Pages 4830-4839
Journal: Journal of Pharmaceutical Sciences - Volume 97, Issue 11, November 2008, Pages 4830-4839
نویسندگان
S. Nicoli, S. Bilzi, P. Santi, M.R. Caira, J. Li, R. Bettini,