کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2487704 1114428 2007 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mechanistic Study of the Effect of Roller Compaction and Lubricant on Tablet Mechanical Strength
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Mechanistic Study of the Effect of Roller Compaction and Lubricant on Tablet Mechanical Strength
چکیده انگلیسی

ABSTRACTHeckel analysis, tablet tensile strength, and indentation hardness were determined for a series of sieved and roller compacted microcrystalline cellulose mixtures under both unlubricated and lubricated conditions with magnesium stearate. These results have been used to evaluate the loss of reworkability following roller compaction for microcrystalline cellulose and show the extent of impact on tableting properties when magnesium stearate is added intragranularly prior to roller compaction. While results consistent with traditional work-hardening are observed as shown by a modest increase in dynamic hardness and mean yield pressure for unlubricated, roller compacted microcrystalline cellulose, it is overshadowed by the overlubrication effect seen during roller compaction and in particular, the subsequent milling step. The common practice of lubricating the feedstock with magnesium stearate to avoid sticking of the material to the compaction rolls appears to be the major cause of decreased mechanical strength of the final compressed tablets.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 5, May 2007, Pages 1342–1355
نویسندگان
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