کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2498386 1556741 2016 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of process parameters on the recrystallization and size control of puerarin using the supercritical fluid antisolvent process
ترجمه فارسی عنوان
اثر پارامترهای فرایند بر کنترل مجدد و اندازه گیری پودرین با استفاده از فرایند ضد انحلال مایع فوق بحرانی
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
چکیده انگلیسی

The purpose of this study was to investigate the influence of the supercritical CO2 processing on the particle size and morphology of puerarin crystals. The process parameters included solvents, temperature, pressures, antisolvent times, addition volumes, antisolvent addition rates and solute concentrations. After being processed, the dramatic reduction of the dimensions and the change of the crystal shape were noticed. Decreasing the antisolvent addition rate, increasing the temperature and the addition volume below 50 ml led to a decrease in size. The new crystal of puerarin generated at the optimal conditions was 30.34 µm. The solvent of methanol and the concentration of 60 mg/ml were found to determine the type and degree of crystallinity of particles. These results showed that this process has the potential to produce a drug recrystallization product with newly generated crystal forms and the size of drug particles could be controlled through the tuning of various experimental conditions.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Asian Journal of Pharmaceutical Sciences - Volume 11, Issue 2, April 2016, Pages 281–291
نویسندگان
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