کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2501215 1557327 2015 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Release kinetics of an amphiphilic photosensitizer by block-polymer nanoparticles
ترجمه فارسی عنوان
سینتیک یک ماده حساس به نور آمفیفیلی را با استفاده از نانو ذرات بلوک پلیمری منتشر می کند
کلمات کلیدی
نانوذرات بلوک پلیمری، انتشار مواد مخدر، عکس حساس کننده، منتقل کردن، برخورد ها
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
چکیده انگلیسی

Block-polymer nanoparticles are now well-known candidates for the delivery of various non-soluble drugs to cells. The release of drugs from these nanoparticles is a major concern related to their efficiency as nanovectors and is still not completely deciphered. Various processes have been identified, depending of both the nature of the block-polymer and those of the drugs used. We focused our interest on an amphiphilic photosensitizer studied for photodynamic treatments of cancer, Pheophorbide-a (Pheo). We studied the transfer of Pheo from poly(ethyleneglycol-b-ϵ-caprolactone) nanoparticles (I) to MCF-7 cancer cells and (II) to models of membranes. Altogether, our results suggest that the delivery of the major part of the Pheo by the nanoparticles occurs via a direct transfer of Pheo from the nanoparticles to the membrane, by collision. A minor process may involve the internalization of a small amount of the nanoplatforms by the cells. So, this research illustrates the great care necessary to address the question of the choice of such nanocarriers, in relation with the properties – in particular the relative hydrophobicity – of the drugs encapsulated, and gives elements to predict the mechanism and the efficiency of the delivery.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 495, Issue 2, 30 November 2015, Pages 750–760
نویسندگان
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