کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2501603 1557348 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Overcoming drug crystallization in electrospun fibers – Elucidating key parameters and developing strategies for drug delivery
ترجمه فارسی عنوان
غلبه بر کریستال شدن داروها در الیاف الکترود اصلاح پارامترهای کلیدی و ایجاد استراتژی برای تحویل دارو
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
چکیده انگلیسی

For the development of novel therapeutics, uncontrolled crystallization of drugs within delivery systems represents a major challenge. Especially for thin and flexible polymeric systems such as oral films or dermal wound dressings, the formation and growth of drug crystals can significantly affect drug distribution and release kinetics as well as physical storage stability. In this context, electrospinning was introduced as a fabrication technique with the potential to encapsulate drugs within ultrafine fibers by rapid solvent evaporation overcoming drug crystallization during fabrication and storage. However, these effects could so far only be shown for specific drug-polymer combinations and an in-depth understanding of the underlying processes of drug-loaded fiber formation and influencing key parameters is still missing.In this study, we systematically investigated crystal formation of caffeine as a model drug in electrospun fibers comparing different polymers. The solvent polarity was found to have a major impact on the drug crystal formation, whereas only a minor effect was attributed to the electrospinning process parameters.Based on an in-depth understanding of the underlying processes determining drug crystallization processes in electrospun fibers, key parameters could be identified which allow for the rational development of drug-loaded electrospun fibers overcoming drug crystallization.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 478, Issue 1, 15 January 2015, Pages 390–397
نویسندگان
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